Naila Rabbani Selected Research

Pyruvaldehyde (Methylglyoxal)

2/2022	Hexokinase-2-Linked Glycolytic Overload and Unscheduled Glycolysis-Driver of Insulin Resistance and Development of Vascular Complications of Diabetes.
1/2022	Methylglyoxal and glyoxalase 1-a metabolic stress pathway-linking hyperglycemia to the unfolded protein response and vascular complications of diabetes.
7/2021	Reversal of Insulin Resistance in Overweight and Obese Subjects by trans-Resveratrol and Hesperetin Combination-Link to Dysglycemia, Blood Pressure, Dyslipidemia, and Low-Grade Inflammation.
1/2021	Dicarbonyl stress, protein glycation and the unfolded protein response.
1/2021	Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome.
10/2020	Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer.
1/2019	Activation of the unfolded protein response in high glucose treated endothelial cells is mediated by methylglyoxal.
1/2018	Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease.
1/2018	Multiple roles of glyoxalase 1-mediated suppression of methylglyoxal glycation in cancer biology-Involvement in tumour suppression, tumour growth, multidrug resistance and target for chemotherapy.
2/2017	Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock Down Alters Collagen Homoeostasis in L6 Myoblasts.

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Naila Rabbani Research Topics

Disease

11	Mitochondrial Diseases (Mitochondrial Disease) 02/2022 - 04/2008
10	Type 2 Diabetes Mellitus (MODY) 02/2022 - 04/2010
9	Insulin Resistance 02/2022 - 01/2016
9	Neoplasms (Cancer) 02/2022 - 09/2010
9	Inflammation (Inflammations) 02/2022 - 03/2012
9	Hyperglycemia 02/2022 - 04/2008
9	Cardiovascular Diseases (Cardiovascular Disease) 01/2019 - 07/2009
7	Arthritis (Polyarthritis) 01/2021 - 04/2012
7	Diabetic Nephropathies (Diabetic Nephropathy) 01/2015 - 09/2010
6	Overweight 02/2022 - 01/2016
6	Obesity 01/2021 - 05/2011
4	Chronic Kidney Failure (Chronic Renal Failure) 01/2016 - 01/2008
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 02/2022 - 01/2012
3	Diabetes Complications 01/2022 - 04/2014
3	Chronic Renal Insufficiency 01/2019 - 04/2014
3	Osteoarthritis 01/2018 - 03/2015
3	Renal Insufficiency (Renal Failure) 01/2016 - 04/2012
3	Alzheimer Disease (Alzheimer's Disease) 04/2014 - 01/2008
3	Parkinson Disease (Parkinson's Disease) 04/2014 - 02/2011
3	Fibrosis (Cirrhosis) 04/2014 - 01/2008
2	Breast Neoplasms (Breast Cancer) 02/2022 - 01/2021
2	Dyslipidemias (Dyslipidemia) 07/2021 - 04/2012
2	Autistic Disorder (Autism) 01/2021 - 01/2018
2	Infections 01/2020 - 05/2011
2	Non-alcoholic Fatty Liver Disease 01/2018 - 01/2016
2	Rheumatoid Arthritis 10/2016 - 03/2015
2	Atherosclerosis 06/2014 - 01/2011
2	Vascular Diseases (Vascular Disease) 04/2014 - 04/2008
2	Uremia 01/2011 - 07/2009
2	Critical Illness (Critically Ill) 09/2009 - 04/2009
2	Burns 09/2009 - 04/2009
1	Diabetes Mellitus 01/2022
1	Prediabetic State (Prediabetes) 01/2021
1	Periodontal Diseases (Periodontal Disease) 10/2020
1	COVID-19 01/2020
1	Diabetic Angiopathies (Diabetic Angiopathy) 01/2019
1	Atrophy 01/2017
1	Hypopigmentation (Hypomelanosis) 01/2017
1	Autism Spectrum Disorder 11/2016
1	Knee Osteoarthritis 10/2016
1	Thiamine Deficiency 01/2016
1	Carcinogenesis 01/2016

Drug/Important Bio-Agent (IBA)

22	Pyruvaldehyde (Methylglyoxal)IBA 02/2022 - 10/2008
21	Proteins (Proteins, Gene)FDA Link 02/2022 - 04/2008
10	Advanced Glycation End ProductsIBA 01/2022 - 01/2012
8	Glucose (Dextrose)FDA LinkGeneric 02/2022 - 04/2009
7	Biomarkers (Surrogate Marker)IBA 01/2021 - 05/2011
6	ResveratrolIBA 02/2022 - 01/2019
6	hesperetinIBA 02/2022 - 01/2019
6	ProteomeIBA 01/2016 - 04/2008
5	Blood Proteins (Serum Proteins)IBA 01/2020 - 07/2009
5	Thiamine (Aneurin)FDA Link 11/2016 - 05/2011
4	DNA (Deoxyribonucleic Acid)IBA 02/2022 - 04/2012
4	ApolipoproteinsIBA 06/2014 - 07/2009
3	Insulin (Novolin)FDA Link 01/2017 - 04/2009
3	cyclic citrullinated peptideIBA 10/2016 - 04/2014
3	Blood Glucose (Blood Sugar)IBA 06/2014 - 04/2009
2	HexosaminesIBA 02/2022 - 10/2008
2	EnzymesIBA 02/2022 - 01/2018
2	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2022 - 04/2012
2	Amino Acids FDA Link 01/2018 - 10/2016
2	Hydroxyproline (4 Hydroxyproline)IBA 01/2018 - 03/2015
2	Arginine (L-Arginine)FDA Link 01/2018 - 04/2010
2	Pharmaceutical PreparationsIBA 10/2016 - 05/2011
2	TransketolaseIBA 01/2016 - 10/2008
2	AntibodiesIBA 03/2015 - 04/2014
2	CreatinineIBA 03/2012 - 09/2009
2	Vitamin B 6IBA 03/2012 - 09/2010
2	oxidized low density lipoproteinIBA 07/2011 - 04/2010
2	LDL Lipoproteins (beta Lipoproteins)IBA 01/2011 - 07/2009
2	Collagen Type IV (Type IV Collagen)IBA 01/2011 - 07/2009
1	ProdrugsIBA 02/2022
1	Protein Kinase CIBA 02/2022
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2021
1	Interleukin-8 (Interleukin 8)IBA 07/2021
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2021
1	UbiquitinIBA 01/2021
1	Ligases (Synthetase)IBA 01/2021
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2020
1	VaccinesIBA 01/2020
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2020
1	Glucose-6-PhosphateIBA 01/2019
1	dityrosineIBA 01/2018
1	glucosepaneIBA 01/2018
1	Peptides (Polypeptides)IBA 01/2018
1	ImmunosorbentsIBA 01/2018
1	imidazoloneIBA 01/2018
1	LeptinIBA 01/2017
1	Interleukin-6 (Interleukin 6)IBA 01/2017
1	LipofuscinIBA 01/2017
1	C-Reactive ProteinIBA 01/2017
1	CollagenIBA 11/2016
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2016
1	OxythiamineIBA 01/2016
1	Thiamine PyrophosphateIBA 01/2016
1	AntimetabolitesIBA 01/2016
1	NitratesIBA 01/2016

Therapy/Procedure

10	Drug Therapy (Chemotherapy) 02/2022 - 09/2010
6	Therapeutics 02/2022 - 04/2009
4	Glycemic Control 01/2021 - 03/2012